Bone Complications of Corticosteroids
Robert S. Lester
Background: Systemic
corticosteroids, a mainstay of treatment for sever dermatosis,
are associated with systemic complications. Adverse effects of
corticosteroids to bone represent a significant adverse effect
that, is poorly understood and poorly managed.
Objectives: The purpose of
this article is to educate dermatologists to the current
understanding of the pathogenesis, diagnosis, and treatment
options available for bone complications of corticosteroids.
Results: Virtually all
patients chronically exposed to high-dose corticosteroid therapy
lose bone mass and are at risk for osteoporotic fractures. In
addition, osteonecrosis is an unpredictable complication of
corticosteroid therapy that may occur with even low-dose
corticosteroids.
Conclusion: Optimal risk
management of corticosteroid therapy includes understanding the
risk factors associated with bone complications and improving
communication with patients.
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